Thiopurines (Azathioprine, Mercaptopurin) updated on 07-28-2025

Low Apgar score (< 7) (at 5 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18482
R78421		 Vestergaard, 2024 Apgar Score at five minutes, <7 during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No Indications: Inflammatory Bowel disease (IBD) 1.12 [0.05;27.63] C 0/111   1/372 1 111
ref
S12241
R46215		 Koslowsky, 2019 Apgar < 8 at 5' throughout pregnancy prospective cohort unexposed, sick Adjustment: No Indications: Inflammatory Bowel disease (IBD) 0.61 [0.01;32.72] C 0/21   0/13 0 21
ref
Total 2 studies 0.88 [0.07;10.71] 1 132
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Vestergaard, 2024Vestergaard, 2024 1.12[0.05; 27.63]111161%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Koslowsky, 2019Koslowsky, 2019 0.61[0.01; 32.72]02139%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.88[0.07; 10.71]11320.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.88[0.07; 10.71]11320%NAVestergaard, 2024 Koslowsky, 2019 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.88[0.07; 10.71]11320%NAVestergaard, 2024 Koslowsky, 2019 2 Tags Adjustment   - No  - No 0.88[0.07; 10.71]11320%NAVestergaard, 2024 Koslowsky, 2019 2 Indications   - Inflammatory Bowel disease (IBD)  - Inflammatory Bowel disease (IBD) 0.88[0.07; 10.71]11320%NAVestergaard, 2024 Koslowsky, 2019 2 All studiesAll studies 0.88[0.07; 10.71]11320%NAVestergaard, 2024 Koslowsky, 2019 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.88[0.07; 10.71]11320%NAVestergaard, 2024 Koslowsky, 2019 20.510.01.0