Thiopurines (Azathioprine, Mercaptopurin) - Medication and Pregnancy KB

Thiopurines (Azathioprine, Mercaptopurin) updated on 07-28-2025

Perinatal death

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S6274 R16869	Norgard (Controls unexposed, NOS), 2003	Perinatal death (stillbirths and deaths during the first week)	throughout pregnancy	population based cohort retrospective	unexposed (general population or NOS) excluded	Adjustment: Yes Indications: Any or not specified	20.00 [2.50;161.40] excluded (control group)	1/10 109/19,418	110	10		ref
S6257 R16685	Norgard (Controls unexposed, sick), 2003	Perinatal death (stillbirths and deaths during the first week)	throughout pregnancy	population based cohort retrospective	unexposed, sick	Adjustment: Yes Indications: Any or not specified	3.20 [0.20;56.90]	1/10 1/30	2	10		ref
					Total	1 studies	3.20 [0.19;53.97]		2	10
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 6274