Thiopurines (Azathioprine, Mercaptopurin) updated on 07-28-2025

Cancer (all kind) in children or adults

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6294
R17067		 Norgard, 2020 Malignancies 3 months (or more) before pregnancy or during pregnancy excluded population based cohort retrospective unexposed (general population or NOS) Adjustment: No Indications: Any or not specified 0.85 [0.21;3.39] C
excluded (exposition period) 		2/1,048   2,952/1,309,961 2,954 1,048
ref
S13762
R53582		 Angelberger, 2011 Malignant disease during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No Indications: Inflammatory Bowel disease (IBD) 1.00 [0.02;53.89] C 0/15   0/15 0 15
ref
S11066
R44833		 Francella, 2003 Neoplasia throughout pregnancy retrospective cohort unexposed, sick Adjustment: No Indications: Inflammatory Bowel disease (IBD) 6.93 [0.13;363.80] C 0/14   0/94 0 14
ref
Total 2 studies 2.65 [0.16;43.99] 0 29
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Angelberger, 2011Angelberger, 2011 1.00[0.02; 53.89]01550%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: criticalROB mesure: moderateROB reporting: moderate Francella, 2003Francella, 2003 6.93[0.13; 363.80]01450%ROB confusion: criticalROB selection: unclearROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 2.65[0.16; 43.99]-290.520.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.65[0.16; 43.99]-290%NAAngelberger, 2011 Francella, 2003 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.65[0.16; 43.99]-290%NAAngelberger, 2011 Francella, 2003 2 Tags Adjustment   - No  - No 2.65[0.16; 43.99]-290%NAAngelberger, 2011 Francella, 2003 2 Indications   - Inflammatory Bowel disease (IBD)  - Inflammatory Bowel disease (IBD) 2.65[0.16; 43.99]-290%NAAngelberger, 2011 Francella, 2003 2 All studiesAll studies 2.65[0.16; 43.99]-290%NAAngelberger, 2011 Francella, 2003 20.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.65[0.16; 43.99]-290%NAAngelberger, 2011 Francella, 2003 20.510.01.0