Thiopurines (Azathioprine, Mercaptopurin) updated on 07-28-2025

Cognitive developmental disorders/delay (3-6 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13740
R53552		 Reynolds, 2022 Developmental delay (NOS) - Median 3.23 years old (1.14, 6.88) throughout pregnancy retrospective cohort unexposed, sick Adjustment: No Indications: Systemic lupus erythematosus (SLE) 1.27 [0.41;3.90] C 5/87   9/196 14 87
ref
Total 1 studies 1.27 [0.41;3.90] 14 87
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Reynolds, 2022Reynolds, 2022 1.27[0.41; 3.90]14870%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.27[0.41; 3.90]1487 -NAReynolds, 2022 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.27[0.41; 3.90]1487 -NAReynolds, 2022 1 Tags Adjustment   - No  - No 1.27[0.41; 3.90]1487 -NAReynolds, 2022 1 Indications   - Systemic lupus erythematosus (SLE)  - Systemic lupus erythematosus (SLE) 1.27[0.41; 3.90]1487 -NAReynolds, 2022 1 All studiesAll studies 1.27[0.41; 3.90]1487 -NAReynolds, 2022 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.27[0.41; 3.90]1487 -NAReynolds, 2022 10.510.01.0