Thiopurines (Azathioprine, Mercaptopurin) updated on 07-28-2025

Minor congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6698
R44254		 Alami, 2017 All minor congenital malformations at least 1st trimester prospective cohort unexposed, sick Adjustment: No Indications: Any or not specified 0.56 [0.10;3.14] C 2/97   4/111 6 97
ref
Total 1 studies 0.56 [0.10;3.14] 6 97
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Alami, 2017Alami, 2017 0.56[0.10; 3.14]6970%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: unclearROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.56[0.10; 3.14]697 -NAAlami, 2017 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.56[0.10; 3.14]697 -NAAlami, 2017 1 Tags Adjustment   - No  - No 0.56[0.10; 3.14]697 -NAAlami, 2017 1 Indications   - Any or not specified  - Any or not specified 0.56[0.10; 3.14]697 -NAAlami, 2017 1 All studiesAll studies 0.56[0.10; 3.14]697 -NAAlami, 2017 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.56[0.10; 3.14]697 -NAAlami, 2017 10.510.01.0