Thiopurines (Azathioprine, Mercaptopurin) updated on 07-28-2025

Urinary malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17723
R74779		 Meyer, 2025 Kidney and urinary tract 1st trimester population based cohort retrospective unexposed, sick Adjustment: Yes Indications: Inflammatory Bowel disease (IBD) 0.91 [0.51;1.64] 14/5,223   85/28,827 99 5,223
ref
S6698
R19114		 Alami, 2017 Reno-urinary tract birth defects at least 1st trimester prospective cohort unexposed, sick Adjustment: No Indications: Any or not specified 0.76 [0.12;4.63] C 2/97   3/111 5 97
ref
Total 2 studies 0.89 [0.51;1.56] 104 5,320
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Meyer, 2025Meyer, 2025 0.91[0.51; 1.64]995,22391%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Alami, 2017Alami, 2017 0.76[0.12; 4.63]5979%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: unclearROB reporting: moderate Total (2 studies) I2 = 0% 0.89[0.51; 1.56]1045,3200.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.89[0.51; 1.56]1045,3200%NAMeyer, 2025 Alami, 2017 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.89[0.51; 1.56]1045,3200%NAMeyer, 2025 Alami, 2017 2 Tags Adjustment   - No  - No 0.76[0.12; 4.63]597 -NAAlami, 2017 1   - Yes  - Yes 0.91[0.51; 1.63]995,223 -NAMeyer, 2025 1 Indications   - Any or not specified  - Any or not specified 0.76[0.12; 4.63]597 -NAAlami, 2017 1   - Inflammatory Bowel disease (IBD)  - Inflammatory Bowel disease (IBD) 0.91[0.51; 1.63]995,223 -NAMeyer, 2025 1 All studiesAll studies 0.89[0.51; 1.56]1045,3200%NAMeyer, 2025 Alami, 2017 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.89[0.51; 1.56]1045,3200%NAMeyer, 2025 Alami, 2017 20.510.01.0