Thiopurines (Azathioprine, Mercaptopurin) updated on 07-28-2025

Chromosomal abnormalities

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17723
R74786
Meyer, 2025 Chromosomal malformations 1st trimester population based cohort retrospective unexposed, sick Adjustment: Yes Indications: Inflammatory Bowel disease (IBD) 3.19 [0.91;11.17] 4/5,223   9/28,827 13 5,223
ref
S6698
R44369
Alami, 2017 Chromosomal abnormalities at least 1st trimester prospective cohort unexposed, sick Adjustment: No Indications: Any or not specified 1.15 [0.07;18.57] C 1/97   1/111 2 97
ref
Total 2 studies 2.68 [0.86;8.42] 15 5,320
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Meyer, 2025Meyer, 2025 3.19[0.91; 11.17]135,22383%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Alami, 2017Alami, 2017 1.15[0.07; 18.57]29717%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: unclearROB reporting: moderate Total (2 studies) I2 = 0% 2.68[0.86; 8.42]155,3200.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.68[0.86; 8.42]155,3200%NAMeyer, 2025 Alami, 2017 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.68[0.86; 8.42]155,3200%NAMeyer, 2025 Alami, 2017 2 Tags Adjustment   - No  - No 1.15[0.07; 18.57]297 -NAAlami, 2017 1   - Yes  - Yes 3.19[0.91; 11.18]135,223 -NAMeyer, 2025 1 Indications   - Any or not specified  - Any or not specified 1.15[0.07; 18.57]297 -NAAlami, 2017 1   - Inflammatory Bowel disease (IBD)  - Inflammatory Bowel disease (IBD) 3.19[0.91; 11.18]135,223 -NAMeyer, 2025 1 All studiesAll studies 2.68[0.86; 8.42]155,3200%NAMeyer, 2025 Alami, 2017 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.68[0.86; 8.42]155,3200%NAMeyer, 2025 Alami, 2017 20.510.01.0