Thiopurines (Azathioprine, Mercaptopurin) updated on 07-28-2025

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13738
R53528		 Nguyen, 2019 Induced abortion during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No Indications: Relapsing-Remitting Multiple Sclerosis (RRMS) 3.82 [0.19;75.80] C 0/4   27/763 27 4
ref
S6698
R52663		 Alami, 2017 Voluntary abortion at least 1st trimester prospective cohort unexposed, sick Adjustment: No Indications: Any or not specified 1.89 [0.80;4.46] C 16/124   9/124 25 124
ref
S10792
R52288		 Casanova, 2013 Elective abortions 3 months (or more) before pregnancy or during pregnancy excluded retrospective cohort exposed to other treatment, sick Adjustment: No Indications: Inflammatory Bowel disease (IBD) 0.56 [0.11;2.81] C
excluded (exposition period) 		2/187   6/318 8 187
ref
Total 2 studies 2.00 [0.88;4.55] 52 128
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Nguyen, 2019Nguyen, 2019 3.82[0.19; 75.80]2748%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: moderateROB mesure: moderateROB reporting: low Alami, 2017Alami, 2017 1.89[0.80; 4.46]2512492%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: unclearROB reporting: moderate Total (2 studies) I2 = 0% 2.00[0.88; 4.55]521280.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.00[0.88; 4.55]521280%NANguyen, 2019 Alami, 2017 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.00[0.88; 4.55]521280%NANguyen, 2019 Alami, 2017 2 Tags Adjustment   - No  - No 2.00[0.88; 4.55]521280%NANguyen, 2019 Alami, 2017 2 Indications   - Any or not specified  - Any or not specified 1.89[0.80; 4.46]25124 -NAAlami, 2017 1   - Relapsing-Remitting Multiple Sclero ...  - Relapsing-Remitting Multiple Sclerosis (RRMS) 3.82[0.19; 75.80]274 -NANguyen, 2019 1 All studiesAll studies 2.00[0.88; 4.55]521280%NANguyen, 2019 Alami, 2017 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.00[0.88; 4.55]521280%NANguyen, 2019 Alami, 2017 20.510.01.0