Thiopurines (Azathioprine, Mercaptopurin) updated on 07-28-2025

Therapeutic terminations of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6698
R52664		 Alami, 2017 Medical abortion (for fetal cause) at least 1st trimester prospective cohort unexposed, sick Adjustment: No Indications: Any or not specified 2.56 [0.49;13.47] C 5/124   2/124 7 124
ref
S8427
R27089		 Goldstein, 2007 Therapeutic abortion at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Indications: Any or not specified 1.20 [0.52;2.80] 11/177   12/230 23 177
ref
S13739
R53531		 Tennenbaum, 1999 Therapeutic termination of pregnancy during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No Indications: Inflammatory Bowel disease (IBD) 4.48 [0.08;237.70] C 0/12   0/52 0 12
ref
Total 3 studies 1.46 [0.70;3.05] 30 313
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Alami, 2017Alami, 2017 2.56[0.49; 13.47]712420%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: unclearROB reporting: moderate Goldstein, 2007Goldstein, 2007 1.20[0.52; 2.80]2317777%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Tennenbaum, 1999Tennenbaum, 1999 4.48[0.08; 237.70]0123%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (3 studies) I2 = 0% 1.46[0.70; 3.05]303130.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.46[0.70; 3.05]303130%NAAlami, 2017 Goldstein, 2007 Tennenbaum, 1999 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.20[0.52; 2.78]23177 -NAGoldstein, 2007 1 unexposed, sickunexposed, sick 2.78[0.60; 12.87]71360%NAAlami, 2017 Tennenbaum, 1999 2 Tags Adjustment   - No  - No 1.46[0.70; 3.05]303130%NAAlami, 2017 Goldstein, 2007 Tennenbaum, 1999 3 Indications   - Any or not specified  - Any or not specified 1.40[0.66; 2.97]303010%NAAlami, 2017 Goldstein, 2007 2   - Inflammatory Bowel disease (IBD)  - Inflammatory Bowel disease (IBD) 4.48[0.08; 237.70]-12 -NATennenbaum, 1999 1 All studiesAll studies 1.46[0.70; 3.05]303130%NAAlami, 2017 Goldstein, 2007 Tennenbaum, 1999 30.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.20[0.52; 2.78]23177 -NAGoldstein, 2007 1 unexposed, sick controlsunexposed, sick controls 2.78[0.60; 12.87]71360%NAAlami, 2017 Tennenbaum, 1999 20.510.01.0