Thiopurines (Azathioprine, Mercaptopurin) updated on 07-28-2025

Macrosomia (> 4000g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10792
R52297		 Casanova, 2013 Fetal macrosomia 3 months (or more) before pregnancy or during pregnancy excluded retrospective cohort exposed to other treatment, sick Adjustment: No Indications: Inflammatory Bowel disease (IBD) 1.70 [0.03;86.16] C
excluded (exposition period) 		0/187   0/318 0 187
ref
S6258
R18097		 Cleary (Controls unexposed, NOS), 2009 Birth weight ≥4500g early pregnancy population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Indications: Any or not specified 0.59 [0.32;1.11] 10/467   46,050/1,140,988 46,060 467
ref
Total 1 studies 0.59 [0.32;1.10] 46,060 467
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Cleary (Controls unexposed, NOS), 2009Cleary, 2009 1 0.59[0.32; 1.11]46,0604670%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.59[0.32; 1.10]46,060467 -NACleary (Controls unexposed, NOS), 2009 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.59[0.32; 1.10]46,060467 -NACleary (Controls unexposed, NOS), 2009 1 Tags Adjustment   - Yes  - Yes 0.59[0.32; 1.10]46,060467 -NACleary (Controls unexposed, NOS), 2009 1 Indications   - Any or not specified  - Any or not specified 0.59[0.32; 1.10]46,060467 -NACleary (Controls unexposed, NOS), 2009 1 All studiesAll studies 0.59[0.32; 1.10]46,060467 -NACleary (Controls unexposed, NOS), 2009 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.59[0.32; 1.10]46,060467 -NACleary (Controls unexposed, NOS), 2009 10.510.01.0