Carbamazepine (Epilepsy) updated on 04-22-2025

Severe cognitive developmental delay (Mental retardation) (> 6 years old)

id	Study   Auto Madley-Dowd_SE (Carbamazepine) (Controls exposed to LTG), 2024Madley-Dowd_SE (Carbamazepine) (Controls unexposed, sick), 2024Madley-Dowd_UK (Carbamazepine) (Controls unexposed, sick), 2024Dreier (Carbamazepine) (Epilepsy) (Controls exposed to LTG), 2023Dreier (Carbamazepine) (Epilepsy) (Controls unexposed, sick), 2023Meador (Carbamazepine), 2013Titze (Carbamazepine) (Controls unexposed, disease free), 2008Titze (Carbamazepine) (Controls unexposed, sick), 2008Viinikainen (Carbamazepine) b, 2006Vinten (Carbamazepine), 2005Gaily (Carbamazepine) (Controls unexposed, disease free), 2004Gaily (Carbamazepine) (Controls unexposed, sick), 2004	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedsiblingwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S17426 R73184	Madley-Dowd_SE (Carbamazepine) (Controls exposed to LTG), 2024	Intellectual disability (intelligence quotient below 70) - ICD-8/9/10 codes - Mean 5-20 years old (according groups°	during pregnancy (anytime or not specified)	population based cohort retrospective	exposed to other treatment, sick excluded	Adjustment: No Partial overlapping	2.17 [1.41;3.33] C excluded (control group)	56/1,842   34/2,383	90	1,842		ref
S17427 R73188	Madley-Dowd_SE (Carbamazepine) (Controls unexposed, sick), 2024	Intellectual disability (intelligence quotient below 70) - ICD-8/9/10 codes - Mean 5-20 years old (according groups)	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed, sick	Adjustment: Yes Partial overlapping	1.44 [1.06;1.97]	56/1,842   194/10,769	250	1,842		ref
S17107 R72199	Madley-Dowd_UK (Carbamazepine) (Controls unexposed, sick), 2024	Intellectual disability - ICD10 codes - Median CBZ 9.17 (5.31-12.54) years old	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	unexposed, sick	Adjustment: Yes	1.75 [0.47;6.59]	-/460   13/4,075	-	460		ref
S15868 R65354	Dreier (Carbamazepine) (Epilepsy) (Controls exposed to LTG), 2023	Intellectual disability - Corresponding ICD-10 F-chapter - Up to 22 years of age	during pregnancy (anytime or not specified)	population based cohort propective	exposed to other treatment, sick excluded	Adjustment: No	2.12 [1.32;3.39] C excluded (control group)	36/2,665   34/5,288	70	2,665		ref
S15869 R65370	Dreier (Carbamazepine) (Epilepsy) (Controls unexposed, sick), 2023	Intellectual disability - Corresponding ICD-10 F-chapter - Up to 22 years of age	during pregnancy (anytime or not specified)	population based cohort propective	unexposed, sick	Adjustment: Yes	1.11 [0.73;1.70]	36/2,665   184/22,203	220	2,665		ref
S386 R17415	Meador (Carbamazepine), 2013	IQ <70 (DAS) (at 6 years old)	during pregnancy (anytime or not specified)	prospective cohort	exposed to other treatment, sick	Adjustment: Yes	3.71 [0.15;92.65] C	1/61   0/74	1	61		ref
S6106 R15984	Titze (Carbamazepine) (Controls unexposed, disease free), 2008	Learning disability (IQ<70) (German versions of the revised Wechsler Intelligence Scales for children and for adults)	during pregnancy (anytime or not specified)	prospective cohort	unexposed, disease free excluded	Adjustment: No Matched	13.86 [0.24;809.27] C excluded (control group)	0/4   0/49	0	4		ref
S6112 R15987	Titze (Carbamazepine) (Controls unexposed, sick), 2008	Learning disability (IQ<70) (German versions of the revised Wechsler Intelligence Scales for children and for adults)	during pregnancy (anytime or not specified)	prospective cohort	unexposed, sick	Adjustment: No	1.10 [0.04;33.38] C	0/4   1/13	1	4		ref
S5831 R14433	Viinikainen (Carbamazepine) b, 2006	Full Scale IQ (FIQ) < 2SD Wechsler Intelligence Scale for Children (WISC III)	throughout pregnancy	prospective cohort	unexposed, sick	Adjustment: No	1.00 [0.02;54.47] C	0/13   0/13	0	13		ref
S5560 R19152	Vinten (Carbamazepine), 2005	IQ score <69 Wechsler Intelligence Scale for Children (WISC III) (Aged between 6 and 16 years)	during pregnancy (anytime or not specified)	retrospective cohort	unexposed, sick	Adjustment: No	1.03 [0.28;3.83] C	4/52   6/80	10	52		ref
S7236 R20865	Gaily (Carbamazepine) (Controls unexposed, disease free), 2004	Mental retardation (Verbal and nonverbal IQ <70)	2nd and/or 3rd trimester	prospective cohort	unexposed, disease free excluded	Adjustment: No	0.54 [0.06;5.29] C excluded (control group)	1/86   3/141	4	86		ref
S5557 R20856	Gaily (Carbamazepine) (Controls unexposed, sick), 2004	Mental retardation (Verbal and nonverbal IQ <70)	2nd and/or 3rd trimester	prospective cohort	unexposed, sick	Adjustment: No	0.25 [0.02;2.87] C	1/86   2/45	3	86		ref
					Total	8 studies	1.30 [1.02;1.65]		485	5,183
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 7236, 6106, 15868, 17426