Carbamazepine (Epilepsy) updated on 04-22-2025

Genital anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17503
R73549		 Wiggs, 2024 Genital organ malformations early pregnancy population based cohort retrospective unexposed, sick Adjustment: Yes 1.54 [0.93;2.55] -/1,456   -/12,666 - 1,456
ref
S302
R15856		 Artama (Carbamazepine), 2005 Genital organs 1st trimester retrospective cohort (registry) unexposed, sick Adjustment: No 0.93 [0.25;3.49] C 4/805   5/939 9 805
ref
Total 2 studies 1.44 [0.90;2.31] 9 2,261
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Wiggs, 2024Wiggs, 2024 1.54[0.93; 2.55]-1,45687%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Artama (Carbamazepine), 2005Artama, 2005 1 0.93[0.25; 3.49]980513%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.44[0.90; 2.31]92,2610.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Carbamazepine;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.44[0.90; 2.31]92,2610%NAWiggs, 2024 Artama (Carbamazepine), 2005 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.44[0.90; 2.31]92,2610%NAWiggs, 2024 Artama (Carbamazepine), 2005 2 Tags Adjustment   - No  - No 0.93[0.25; 3.49]9805 -NAArtama (Carbamazepine), 2005 1   - Yes  - Yes 1.54[0.93; 2.55]-1,456 -NAWiggs, 2024 1 All studiesAll studies 1.44[0.90; 2.31]92,2610%NAWiggs, 2024 Artama (Carbamazepine), 2005 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.44[0.90; 2.31]92,2610%NAWiggs, 2024 Artama (Carbamazepine), 2005 20.510.01.0