Carbamazepine (Epilepsy) updated on 04-22-2025

Chromosomal abnormalities

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17503
R73552		 Wiggs, 2024 Chromosomal abnormality early pregnancy population based cohort retrospective unexposed, sick Adjustment: Yes 0.78 [0.19;3.28] -/1,456   -/12,666 - 1,456
ref
S302
R15861		 Artama (Carbamazepine), 2005 Chromosomal anomalies 1st trimester retrospective cohort (registry) unexposed, sick Adjustment: No 8.20 [0.42;158.93] C 3/805   0/939 3 805
ref
Total 2 studies 1.74 [0.20;15.47] 3 2,261
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Wiggs, 2024Wiggs, 2024 0.78[0.19; 3.28]-1,45666%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Artama (Carbamazepine), 2005Artama, 2005 1 8.20[0.42; 158.93]380534%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 49% 1.74[0.20; 15.47]32,2610.220.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Carbamazepine;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.74[0.20; 15.47]32,26149%NAWiggs, 2024 Artama (Carbamazepine), 2005 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.74[0.20; 15.47]32,26149%NAWiggs, 2024 Artama (Carbamazepine), 2005 2 Tags Adjustment   - No  - No 8.20[0.42; 158.93]3805 -NAArtama (Carbamazepine), 2005 1   - Yes  - Yes 0.78[0.19; 3.24]-1,456 -NAWiggs, 2024 1 All studiesAll studies 1.74[0.20; 15.47]32,26149%NAWiggs, 2024 Artama (Carbamazepine), 2005 20.220.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.74[0.20; 15.47]32,26149%NAWiggs, 2024 Artama (Carbamazepine), 2005 20.510.01.0