Carbamazepine (Epilepsy)

Very preterm (28 to 32 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10075
R36689		 Coste (Carbamazepine), 2020 Gestational age at birth (< 32 WA) during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick Adjustment: No 3.02 [0.64;14.32] C 2/176   8/2,108 10 176
ref
Total 1 studies 3.02 [0.64;14.32] 10 176
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Coste (Carbamazepine), 2020Coste, 2020 1 3.02[0.64; 14.32]101760%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: moderateROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Carbamazepine;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.02[0.64; 14.32]10176 -NACoste (Carbamazepine), 2020 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 3.02[0.64; 14.32]10176 -NACoste (Carbamazepine), 2020 1 Tags Adjustment   - No  - No 3.02[0.64; 14.32]10176 -NACoste (Carbamazepine), 2020 1 All studiesAll studies 3.02[0.64; 14.32]10176 -NACoste (Carbamazepine), 2020 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 3.02[0.64; 14.32]10176 -NACoste (Carbamazepine), 2020 10.510.01.0