Phenytoin (Epilepsy)

Neural Tube Defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6501
R17862		 Bànhidy (Phenytoin), 2011 Neural tube defects throughout pregnancy case control unexposed, sick Adjustment: No Matched 0.53 [0.03;9.34] C 1/20   1/11 2 20
ref
Total 1 studies 0.53 [0.03;9.34] 2 20
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bànhidy (Phenytoin), 2011Bànhidy, 2011 1 0.53[0.03; 9.34]2200%ROB confusion: criticalROB selection: criticalROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenytoin;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.53[0.03; 9.34]220 -NABànhidy (Phenytoin), 2011 1 Type of controls unexposed, sickunexposed, sick 0.53[0.03; 9.34]220 -NABànhidy (Phenytoin), 2011 1 Tags Adjustment   - No  - No 0.53[0.03; 9.34]220 -NABànhidy (Phenytoin), 2011 1 MatchedMatched 0.53[0.03; 9.34]220 -NABànhidy (Phenytoin), 2011 1 All studiesAll studies 0.53[0.03; 9.34]220 -NABànhidy (Phenytoin), 2011 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale14.54[0.54; 391.72]17 -NAMawer (Phenytoin) (Controls unexposed, disease free), 2010 1 unexposed, sick controlsunexposed, sick controls 2.57[0.37; 17.71]3714%NAVajda (Phenytoin) (Controls unexposed, sick), 2013 Bànhidy (Phenytoin), 2011 Mawer (Phenytoin) (Controls unexposed, sick), 2010 3 exposed to other treatment, sick controlsexposed to other treatment, sick controls 5.71[1.38; 23.67]66740%NATomson (Phenytoin), 2018 Vajda (Phenytoin) (Controls exposed to Lamotrigine, sick), 2013 Hernández-Díaz (Phenytoin) (Controls exposed to Lamotrigine, sick), 2012 Mawer (Phenytoin) (Controls exposed to Lamotrigine, sick), 2010 Morrow (Phenytoin) (Controls exposed to Lamotrigine, sick), 2006 50.510.01.0