Phenytoin (Epilepsy) updated on 04-22-2025

ADHD (Attention deficit hyperactivity disorder): Risk

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7292
R21110		 Cohen (Phenytoin), 2013 Children with either ADHD inattentive OR combined types > 1 SD (from the Attention Problems and Hyperactivity scales of the BASC) (Parent) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick Adjustment: No 0.53 [0.10;2.73] C 2/31   7/61 9 31
ref
Total 1 studies 0.53 [0.10;2.73] 9 31
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Cohen (Phenytoin), 2013Cohen, 2013 1 0.53[0.10; 2.73]9310%ROB confusion: criticalROB selection: lowROB classification: lowROB missing: criticalROB mesure: lowROB reporting: low0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenytoin;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.53[0.10; 2.73]931 -NACohen (Phenytoin), 2013 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 0.53[0.10; 2.73]931 -NACohen (Phenytoin), 2013 1 Tags Adjustment   - No  - No 0.53[0.10; 2.73]931 -NACohen (Phenytoin), 2013 1 All studiesAll studies 0.53[0.10; 2.73]931 -NACohen (Phenytoin), 2013 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.53[0.10; 2.73]931 -NACohen (Phenytoin), 2013 10.510.01.0