Phenytoin (Epilepsy)

Learning disorders

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5491
R25809		 Forsberg (Phenytoin) (Controls unexposed NOS), 2011 School grades: Swedish - not passed (at 16 years) during pregnancy (anytime or not specified) retrospective cohort (registry) unexposed (general population or NOS) excluded Adjustment: No 1.17 [0.81;1.69]
excluded (control group) 		49/288   177,179/1,179,536 177,228 288
ref
S9971
R35845		 Forsberg (Phenytoin) (Controls unexposed, sick), 2011 School grades: English - not passed (at 16 years) during pregnancy (anytime or not specified) retrospective cohort (registry) unexposed, sick Adjustment: No 0.88 [0.53;1.47] C 47/288   29/160 76 288
ref
Total 1 studies 0.88 [0.53;1.47] 76 288
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Forsberg (Phenytoin) (Controls unexposed, sick), 2011Forsberg, 2011 1 0.88[0.53; 1.47]762880%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenytoin) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.88[0.53; 1.47]76288 -NAForsberg (Phenytoin) (Controls unexposed, sick), 2011 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.88[0.53; 1.47]76288 -NAForsberg (Phenytoin) (Controls unexposed, sick), 2011 1 Tags Adjustment   - No  - No 0.88[0.53; 1.47]76288 -NAForsberg (Phenytoin) (Controls unexposed, sick), 2011 1 All studiesAll studies 0.88[0.53; 1.47]76288 -NAForsberg (Phenytoin) (Controls unexposed, sick), 2011 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 5491

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.17[0.81; 1.69]177,228288 -NAForsberg (Phenytoin) (Controls unexposed NOS), 2011 1 unexposed, sick controlsunexposed, sick controls 0.88[0.53; 1.47]76288 -NAForsberg (Phenytoin) (Controls unexposed, sick), 2011 10.510.01.0