Phenytoin (Epilepsy) updated on 04-22-2025

Genital anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6098
R15893		 Artama (Phenytoin), 2005 Genital organs 1st trimester retrospective cohort (registry) unexposed, sick Adjustment: No 2.26 [0.12;41.69] C 0/38   5/939 5 38
ref
Total 1 studies 2.26 [0.12;41.69] 5 38
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Artama (Phenytoin), 2005Artama, 2005 1 2.26[0.12; 41.69]5380%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenytoin;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.26[0.12; 41.69]538 -NAArtama (Phenytoin), 2005 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.26[0.12; 41.69]538 -NAArtama (Phenytoin), 2005 1 Tags Adjustment   - No  - No 2.26[0.12; 41.69]538 -NAArtama (Phenytoin), 2005 1 All studiesAll studies 2.26[0.12; 41.69]538 -NAArtama (Phenytoin), 2005 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.26[0.12; 41.69]538 -NAArtama (Phenytoin), 2005 10.510.01.0