Phenytoin (Epilepsy) updated on 04-22-2025

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S16089
R66765		 Christensen (Phenytoin) (Epilepsy) (Controls exposed to LTG), 2024 Low birth weight (<2500 g) during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 2.28 [0.97;5.34] C
excluded (control group) 		6/64   230/5,299 236 64
ref
S16050
R66614		 Christensen (Phenytoin) (Epilepsy) (Controls unexposed, general population), 2024 Low birth weight (<2500 g) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 1.94 [0.76;4.95] 6/64   1,006/22,227 1,012 64
ref
Total 1 studies 1.94 [0.76;4.95] 1,012 64
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Christensen (Phenytoin) (Epilepsy) (Controls unexposed, general population), 2024Christensen, 2024 1 1.94[0.76; 4.95]1,012640%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Phenytoin) (Epilepsy) (Controls unexposed, general population;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.94[0.76; 4.95]1,01264 -NAChristensen (Phenytoin) (Epilepsy) (Controls unexposed, general population), 2024 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.94[0.76; 4.95]1,01264 -NAChristensen (Phenytoin) (Epilepsy) (Controls unexposed, general population), 2024 1 Tags Adjustment   - Yes  - Yes 1.94[0.76; 4.95]1,01264 -NAChristensen (Phenytoin) (Epilepsy) (Controls unexposed, general population), 2024 1 All studiesAll studies 1.94[0.76; 4.95]1,01264 -NAChristensen (Phenytoin) (Epilepsy) (Controls unexposed, general population), 2024 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 16089

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.94[0.76; 4.95]1,01264 -NAChristensen (Phenytoin) (Epilepsy) (Controls unexposed, general population), 2024 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.28[0.97; 5.34]23664 -NAChristensen (Phenytoin) (Epilepsy) (Controls exposed to LTG), 2024 10.510.01.0