Valproate (Epilepsy)

Postpartum hemorrhage

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6261
R16733		 Borthen (Valproate) (Controls exposed to Lamotrigine, sick), 2010 Haemorrhage ≥ 500 ml during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.96 [0.61;1.53] C
excluded (control group) 		43/215   48/233 91 215
ref
S5684
R16678		 Borthen (Valproate) (Controls unexposed, disease free), 2010 Haemorrhage ≥ 500 ml during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free excluded Adjustment: Yes 2.10 [1.50;3.00]
excluded (control group) 		43/215   49,252/362,302 49,295 215
ref
S6263
R16749		 Borthen (Valproate) (Controls unexposed, sick), 2010 Haemorrhage ≥ 500 ml during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: No 1.44 [1.01;2.06] C 43/215   276/1,863 319 215
ref
Total 1 studies 1.44 [1.01;2.06] 319 215
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Borthen (Valproate) (Controls unexposed, sick), 2010Borthen, 2010 1 1.44[1.01; 2.06]3192150%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Valproate) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.44[1.01; 2.06]319215 -NABorthen (Valproate) (Controls unexposed, sick), 2010 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.44[1.01; 2.06]319215 -NABorthen (Valproate) (Controls unexposed, sick), 2010 1 Tags Adjustment   - No  - No 1.44[1.01; 2.06]319215 -NABorthen (Valproate) (Controls unexposed, sick), 2010 1 All studiesAll studies 1.44[1.01; 2.06]319215 -NABorthen (Valproate) (Controls unexposed, sick), 2010 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 6261, 5684

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.10[1.48; 2.97]49,295215 -NABorthen (Valproate) (Controls unexposed, disease free), 2010 1 unexposed, sick controlsunexposed, sick controls 1.44[1.01; 2.06]319215 -NABorthen (Valproate) (Controls unexposed, sick), 2010 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.96[0.61; 1.53]91215 -NABorthen (Valproate) (Controls exposed to Lamotrigine, sick), 2010 10.510.01.0