Valproate (Epilepsy)

Cleft lip with or without cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6168
R16233		 Viinikainen (Valproate) (Controls unexposed, sick) a, 2006 Cleft lip throughout pregnancy prospective cohort unexposed, sick Adjustment: No 1.87 [0.04;96.99] C 0/28   0/52 0 28
ref
S6099
R15907		 Artama (Valproate), 2005 Cleft lip/ cleft palate 1st trimester retrospective cohort (registry) unexposed, sick Adjustment: No 9.08 [1.75;47.07] C 5/263   2/939 7 263
ref
Total 2 studies 7.19 [1.57;32.82] 7 291
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Viinikainen (Valproate) (Controls unexposed, sick) a, 2006Viinikainen, 2006 1 1.87[0.04; 96.99]02815%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Artama (Valproate), 2005Artama, 2005 2 9.08[1.75; 47.07]726385%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 7.19[1.57; 32.82]72910.520.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Valproate) (Controls unexposed, sick) ; 2: Valproate;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 7.19[1.57; 32.82]72910%NAViinikainen (Valproate) (Controls unexposed, sick) a, 2006 Artama (Valproate), 2005 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 7.19[1.57; 32.82]72910%NAViinikainen (Valproate) (Controls unexposed, sick) a, 2006 Artama (Valproate), 2005 2 Tags Adjustment   - No  - No 7.19[1.57; 32.82]72910%NAViinikainen (Valproate) (Controls unexposed, sick) a, 2006 Artama (Valproate), 2005 2 All studiesAll studies 7.19[1.57; 32.82]72910%NAViinikainen (Valproate) (Controls unexposed, sick) a, 2006 Artama (Valproate), 2005 20.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 7.19[1.57; 32.82]72910%NAViinikainen (Valproate) (Controls unexposed, sick) a, 2006 Artama (Valproate), 2005 20.510.01.0