Valproate (Epilepsy) updated on 04-22-2025

Fetal distress

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7231
R20843		 McVearry (Valproate), 2009 Fetal distress during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick Adjustment: No 0.09 [0.00;1.83] C 0/16   4/17 4 16
ref
S5495
R16098		 Jäger-Roman (Valproate), 1986 Distressed infants (during labor) (i.e., fetal heart tones with late decelerations, silent or accelerated beat-to-beat variations) at least 1st trimester excluded prospective cohort unexposed (general population or NOS) Adjustment: No 9.00 [1.50;53.86] C
excluded (exposition period) 		6/14   2/26 8 14
ref
Total 1 studies 0.09 [0.00;1.83] 4 16
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF McVearry (Valproate), 2009McVearry, 2009 1 0.09[0.00; 1.83]4160%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.02.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Valproate;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.09[0.00; 1.83]416 -NAMcVearry (Valproate), 2009 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 0.09[0.00; 1.83]416 -NAMcVearry (Valproate), 2009 1 Tags Adjustment   - No  - No 0.09[0.00; 1.83]416 -NAMcVearry (Valproate), 2009 1 All studiesAll studies 0.09[0.00; 1.83]416 -NAMcVearry (Valproate), 2009 10.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.09[0.00; 1.83]416 -NAMcVearry (Valproate), 2009 10.510.01.0