Valproate (Epilepsy)

Polydactyly

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7663
R22690		 Tomson (Valproate), 2018 Polydactyly at least 1st trimester prospective cohort exposed to other treatment, sick Adjustment: No 31.13 [1.80;539.82] C 8/1,381   0/2,514 8 1,381
ref
S6505
R17914		 Bànhidy (Valproate), 2011 Poly/syndactyly throughout pregnancy case control unexposed, sick Adjustment: No Matched 0.58 [0.02;16.72] C 0/5   2/12 2 5
ref
S6168
R16232		 Viinikainen (Valproate) (Controls unexposed, sick) a, 2006 Polydactyly throughout pregnancy prospective cohort unexposed, sick Adjustment: No 1.87 [0.04;96.99] C 0/28   0/52 0 28
ref
S6687
R18640		 D'Souza (Valproate) (Controls unexposed, disease free), 1991 Extra digits throughout pregnancy prospective cohort unexposed, disease free excluded Adjustment: No Matched 123.00 [1.00;15058.31] C
excluded (control group) 		0/1   0/62 0 1
ref
S6695
R18801		 D'Souza (Valproate) (Controls unexposed, sick), 1991 Extra digits throughout pregnancy prospective cohort unexposed, sick Adjustment: No 15.00 [0.12;1923.88] C 0/1   0/8 0 1
ref
Total 4 studies 5.06 [0.71;36.27] 10 1,415
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Tomson (Valproate), 2018Tomson, 2018 1 31.13[1.80; 539.82]81,38136%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Bànhidy (Valproate), 2011Bànhidy, 2011 2 0.58[0.02; 16.72]2528%ROB confusion: criticalROB selection: criticalROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Viinikainen (Valproate) (Controls unexposed, sick) a, 2006Viinikainen, 2006 3 1.87[0.04; 96.99]02821%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate D'Souza (Valproate) (Controls unexposed, sick), 1991D'Souza, 1991 4 15.00[0.12; 1923.88]0115%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (4 studies) I2 = 16% 5.06[0.71; 36.27]101,4150.2100.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Valproate; 2: Valproate; 3: Valproate) (Controls unexposed, sick) ; 4: Valproate) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 12.39[1.54; 99.94]81,4100%NATomson (Valproate), 2018 Viinikainen (Valproate) (Controls unexposed, sick) a, 2006 D'Souza (Valproate) (Controls unexposed, sick), 1991 3 case control studiescase control studies 0.58[0.02; 16.72]25 -NABànhidy (Valproate), 2011 1 Type of controls unexposed, sickunexposed, sick 1.73[0.18; 16.66]2340%NABànhidy (Valproate), 2011 Viinikainen (Valproate) (Controls unexposed, sick) a, 2006 D'Souza (Valproate) (Controls unexposed, sick), 1991 3 exposed to other treatment, sickexposed to other treatment, sick 31.13[1.80; 539.82]81,381 -NATomson (Valproate), 2018 1 Tags Adjustment   - No  - No 5.06[0.71; 36.27]101,41516%NATomson (Valproate), 2018 Bànhidy (Valproate), 2011 Viinikainen (Valproate) (Controls unexposed, sick) a, 2006 D'Souza (Valproate) (Controls unexposed, sick), 1991 4 MatchedMatched 0.58[0.02; 16.72]25 -NABànhidy (Valproate), 2011 1 All studiesAll studies 5.06[0.71; 36.27]101,41516%NATomson (Valproate), 2018 Bànhidy (Valproate), 2011 Viinikainen (Valproate) (Controls unexposed, sick) a, 2006 D'Souza (Valproate) (Controls unexposed, sick), 1991 40.2100.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-5.87.42.9720.000Tomson (Valproate), 2018Bànhidy (Valproate), 2011Viinikainen (Valproate) (Controls unexposed, sick) a, 2006D'Souza (Valproate) (Controls unexposed, sick), 1991

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded 6687

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale123.00[1.00; 15058.31]-1 -NAD'Souza (Valproate) (Controls unexposed, disease free), 1991 1 unexposed, sick controlsunexposed, sick controls 1.73[0.18; 16.66]2340%NABànhidy (Valproate), 2011 Viinikainen (Valproate) (Controls unexposed, sick) a, 2006 D'Souza (Valproate) (Controls unexposed, sick), 1991 3 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale31.13[1.80; 539.82]81,381 -NATomson (Valproate), 2018 10.510.01.0