Valproate (Epilepsy)

Abruptio placentae (retroplacental hematoma)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8143
R25026		 Cohen (Valproate) (Controls exposed to Lamotrigine, sick), 2019 Placental abruption early pregnancy retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: Yes 0.55 [0.15;2.03]
excluded (control group) 		-/-   -/- - -
ref
S8139
R24998		 Cohen (Valproate) (Controls unexposed NOS), 2019 Placental abruption early pregnancy retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 0.63 [0.19;2.10] -/-   20,269/1,440,631 20,260 -
ref
Total 1 studies 0.63 [0.19;2.09] 20,260 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Cohen (Valproate) (Controls unexposed NOS), 2019Cohen, 2019 1 0.63[0.19; 2.10]20,260-0%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Valproate) (Controls unexposed NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.63[0.19; 2.09]20,260- -NACohen (Valproate) (Controls unexposed NOS), 2019 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.63[0.19; 2.09]20,260- -NACohen (Valproate) (Controls unexposed NOS), 2019 1 Tags Adjustment   - Yes  - Yes 0.63[0.19; 2.09]20,260- -NACohen (Valproate) (Controls unexposed NOS), 2019 1 All studiesAll studies 0.63[0.19; 2.09]20,260- -NACohen (Valproate) (Controls unexposed NOS), 2019 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 8143

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.63[0.19; 2.09]20,260- -NACohen (Valproate) (Controls unexposed NOS), 2019 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.55[0.15; 2.02]-- -NACohen (Valproate) (Controls exposed to Lamotrigine, sick), 2019 10.510.01.0