Valproate (Epilepsy) updated on 04-22-2025

Child/Infant growth abnormalities (> 1 year)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6416
R17620		 Pennell (Valproate), 2012 Small for gestational age (SGA) (at 36 months) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick Adjustment: No 0.24 [0.03;2.07] C 1/44   6/68 7 44
ref
Total 1 studies 0.24 [0.03;2.07] 7 44
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Pennell (Valproate), 2012Pennell, 2012 1 0.24[0.03; 2.07]7440%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Valproate;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.24[0.03; 2.07]744 -NAPennell (Valproate), 2012 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 0.24[0.03; 2.07]744 -NAPennell (Valproate), 2012 1 Tags Adjustment   - No  - No 0.24[0.03; 2.07]744 -NAPennell (Valproate), 2012 1 All studiesAll studies 0.24[0.03; 2.07]744 -NAPennell (Valproate), 2012 10.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.24[0.03; 2.07]744 -NAPennell (Valproate), 2012 10.510.01.0