Valproate (Epilepsy) updated on 04-22-2025

Child/Infant head circumference abnormalities (> 1 year)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6416
R17623		 Pennell (Valproate), 2012 Microcephaly (at 36 months) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick Adjustment: No 1.39 [0.03;71.26] C 0/42   0/58 0 42
ref
Total 1 studies 1.39 [0.03;71.26] 0 42
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Pennell (Valproate), 2012Pennell, 2012 1 1.39[0.03; 71.26]0420%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Valproate;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.39[0.03; 71.26]-42 -NAPennell (Valproate), 2012 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 1.39[0.03; 71.26]-42 -NAPennell (Valproate), 2012 1 Tags Adjustment   - No  - No 1.39[0.03; 71.26]-42 -NAPennell (Valproate), 2012 1 All studiesAll studies 1.39[0.03; 71.26]-42 -NAPennell (Valproate), 2012 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.39[0.03; 71.26]-42 -NAPennell (Valproate), 2012 10.510.01.0