Valproate (Epilepsy)

Child/Infant lenght abnormalities (> 1 year)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S371
R18367		 Kini (Valproate) (Controls unexposed, sick), 2006 Height <3rd centile during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 2.55 [0.69;9.43] C 6/63   4/101 10 63
ref
Total 1 studies 2.55 [0.69;9.43] 10 63
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kini (Valproate) (Controls unexposed, sick), 2006Kini, 2006 1 2.55[0.69; 9.43]10630%ROB confusion: criticalROB selection: criticalROB classification: lowROB missing: unclearROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Valproate) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.55[0.69; 9.43]1063 -NAKini (Valproate) (Controls unexposed, sick), 2006 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.55[0.69; 9.43]1063 -NAKini (Valproate) (Controls unexposed, sick), 2006 1 Tags Adjustment   - No  - No 2.55[0.69; 9.43]1063 -NAKini (Valproate) (Controls unexposed, sick), 2006 1 All studiesAll studies 2.55[0.69; 9.43]1063 -NAKini (Valproate) (Controls unexposed, sick), 2006 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.55[0.69; 9.43]1063 -NAKini (Valproate) (Controls unexposed, sick), 2006 10.510.01.0