Valproate (Epilepsy)

Neonatal intracranial hemorrhage

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6623
R18197		 Burja (Valproate) (Controls unexposed, disease free), 2006 Intracranial hemorrhage during pregnancy (anytime or not specified) retrospective cohort (registry) unexposed, disease free excluded Adjustment: No 41.20 [2.24;756.57] C
excluded (control group) 		1/2   5/211 6 2
ref
S6619
R18177		 Burja (Valproate) (Controls unexposed, sick), 2006 Intracranial hemorrhage during pregnancy (anytime or not specified) retrospective cohort (registry) unexposed, sick Adjustment: No 15.00 [0.66;339.57] C 1/2   2/32 3 2
ref
S6687
R18658		 D'Souza (Valproate) (Controls unexposed, disease free), 1991 Periventricular haemorrhage (germinal layer) throughout pregnancy prospective cohort unexposed, disease free excluded Adjustment: No Matched 123.00 [1.00;15058.31] C
excluded (control group) 		0/1   0/62 0 1
ref
S6695
R18819		 D'Souza (Valproate) (Controls unexposed, sick), 1991 Periventricular haemorrhage (germinal layer) throughout pregnancy prospective cohort unexposed, sick Adjustment: No 15.00 [0.12;1923.88] C 0/1   0/8 0 1
ref
Total 2 studies 15.00 [1.09;206.94] 3 3
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Burja (Valproate) (Controls unexposed, sick), 2006Burja, 2006 1 15.00[0.66; 339.57]3271%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA D'Souza (Valproate) (Controls unexposed, sick), 1991D'Souza, 1991 2 15.00[0.12; 1923.88]0129%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 15.00[1.09; 206.94]330.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Valproate) (Controls unexposed, sick; 2: Valproate) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 15.00[1.09; 206.94]330%NABurja (Valproate) (Controls unexposed, sick), 2006 D'Souza (Valproate) (Controls unexposed, sick), 1991 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 15.00[1.09; 206.94]330%NABurja (Valproate) (Controls unexposed, sick), 2006 D'Souza (Valproate) (Controls unexposed, sick), 1991 2 Tags Adjustment   - No  - No 15.00[1.09; 206.94]330%NABurja (Valproate) (Controls unexposed, sick), 2006 D'Souza (Valproate) (Controls unexposed, sick), 1991 2 All studiesAll studies 15.00[1.09; 206.94]330%NABurja (Valproate) (Controls unexposed, sick), 2006 D'Souza (Valproate) (Controls unexposed, sick), 1991 20.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 6687, 6623

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale55.24[4.58; 666.11]630%NABurja (Valproate) (Controls unexposed, disease free), 2006 D'Souza (Valproate) (Controls unexposed, disease free), 1991 2 unexposed, sick controlsunexposed, sick controls Out of scale15.00[1.09; 206.94]330%NABurja (Valproate) (Controls unexposed, sick), 2006 D'Souza (Valproate) (Controls unexposed, sick), 1991 20.510.01.0