Valproate (Epilepsy) updated on 04-22-2025

Severe cognitive developmental delay (Mental retardation) (< 3 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7304
R21148		 Meador (Valproate), 2013 the Bayley Scales of Infant Development (BSID) <70 (at 2 years old) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick Adjustment: Yes 3.29 [1.00;10.85] C 7/29   6/68 13 29
ref
Total 1 studies 3.29 [1.00;10.85] 13 29
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Meador (Valproate), 2013Meador, 2013 1 3.29[1.00; 10.85]13290%ROB confusion: moderateROB selection: lowROB classification: lowROB missing: moderateROB mesure: lowROB reporting: low0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Valproate;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.29[1.00; 10.85]1329 -NAMeador (Valproate), 2013 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 3.29[1.00; 10.85]1329 -NAMeador (Valproate), 2013 1 Tags Adjustment   - Yes  - Yes 3.29[1.00; 10.85]1329 -NAMeador (Valproate), 2013 1 All studiesAll studies 3.29[1.00; 10.85]1329 -NAMeador (Valproate), 2013 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 3.29[1.00; 10.85]1329 -NAMeador (Valproate), 2013 10.510.01.0