Gabapentin (Epilepsy) updated on 04-22-2025

ASD (Autism spectrum disorder): Diagnosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17399
R72947		 Madley-Dowd_SE (Gabapentin) (Controls unexposed, sick), 2024 Autism - ICD-8/9/10 codes - Mean 5-20 years old (according groups) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 0.60 [0.08;4.30] -/43   425/10,769 - 43
ref
S17429
R73207		 Madley-Dowd_SE (Gabapentin) (Controls unexposed, sick), 2024 Autism - ICD-8/9/10 codes - Mean 5-20 years old (according groups) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick excluded Adjustment: Yes Partial overlapping 0.60 [0.08;4.30]
excluded (control group) 		-/43   425/10,769 - 43
ref
S17250
R72201		 Madley-Dowd_UK (Gabapentin) (Controls unexposed, sick) (Epilepsy), 2024 Autism - ICD10 codes - Median 4.93 (3.11-7.46) years old during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: Yes 2.16 [0.19;25.22] -/18   78/4,075 - 18
ref
S6184
R16279		 Wood (Gabapentin), 2015 Score >30 (CARS) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick Adjustment: No 17.00 [0.13;2166.90] C 0/1   0/9 0 1
ref
Total 3 studies 1.30 [0.30;5.66] 0 62
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Madley-Dowd_SE (Gabapentin) (Controls unexposed, sick), 2024Madley-Dowd_SE, 2024 1 0.60[0.08; 4.30]-4355%ROB confusion: moderateROB selection: lowROB classification: lowROB missing: lowROB mesure: criticalROB reporting: moderate Madley-Dowd_UK (Gabapentin) (Controls unexposed, sick) (Epilepsy), 2024Madley-Dowd_UK, 2024 2 2.16[0.19; 25.22]-1836%ROB confusion: moderateROB selection: lowROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate Wood (Gabapentin), 2015Wood, 2015 3 17.00[0.13; 2166.90]019%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: criticalROB mesure: lowROB reporting: moderate Total (3 studies) I2 = 0% 1.30[0.30; 5.66]-620.250.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Gabapentin) (Controls unexposed, sick; 2: Gabapentin) (Controls unexposed, sick) (Epilepsy; 3: Gabapentin;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.30[0.30; 5.66]-620%NAMadley-Dowd_SE (Gabapentin) (Controls unexposed, sick), 2024 Madley-Dowd_UK (Gabapentin) (Controls unexposed, sick) (Epilepsy), 2024 Wood (Gabapentin), 2015 3 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.00[0.21; 4.69]-610%NAMadley-Dowd_SE (Gabapentin) (Controls unexposed, sick), 2024 Madley-Dowd_UK (Gabapentin) (Controls unexposed, sick) (Epilepsy), 2024 2 exposed to other treatment, sickexposed to other treatment, sick 17.00[0.13; 2166.90]-1 -NAWood (Gabapentin), 2015 1 Tags Adjustment   - No  - No 17.00[0.13; 2166.90]-1 -NAWood (Gabapentin), 2015 1   - Yes  - Yes 1.00[0.21; 4.69]-610%NAMadley-Dowd_SE (Gabapentin) (Controls unexposed, sick), 2024 Madley-Dowd_UK (Gabapentin) (Controls unexposed, sick) (Epilepsy), 2024 2 All studiesAll studies 1.30[0.30; 5.66]-620%NAMadley-Dowd_SE (Gabapentin) (Controls unexposed, sick), 2024 Madley-Dowd_UK (Gabapentin) (Controls unexposed, sick) (Epilepsy), 2024 Wood (Gabapentin), 2015 30.250.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 17429

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.83[0.24; 2.80]9011040%NAMadley-Dowd_SE (Gabapentin) (Controls unexposed, sick), 2024 Madley-Dowd_SE (Gabapentin) (Controls unexposed, sick), 2024 Madley-Dowd_UK (Gabapentin) (Controls unexposed, sick) (Epilepsy), 2024 3 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale17.00[0.13; 2166.90]-1 -NAWood (Gabapentin), 2015 10.510.01.0