Gabapentin (Epilepsy) updated on 04-22-2025

Cognitive developmental disorders/delay (3-6 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17428
R73220		 Madley-Dowd_SE (Gabapentin) (Controls exposed to LTG), 2024 Intellectual disability (intelligence quotient below 70) - ICD-8/9/10 codes - Mean 5-20 years old (according groups_Followup Gabapentin 5.24 (3.05-9.34)) during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No Partial overlapping 0.80 [0.05;13.28] C
excluded (control group) 		0/43   34/2,383 34 43
ref
S17399
R72952		 Madley-Dowd_SE (Gabapentin) (Controls unexposed, sick), 2024 Intellectual disability (intelligence quotient below 70) - ICD-8/9/10 codes - Mean 5-20 years old (according groups _ Median follow up Gabapentin 5.24 (3.05-9.34) years old) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: No 0.64 [0.04;10.43] C 0/43   194/10,769 194 43
ref
S17429
R73221		 Madley-Dowd_SE (Gabapentin) (Controls unexposed, sick), 2024 Intellectual disability (intelligence quotient below 70) - ICD-8/9/10 codes - Mean 5-20 years old (according groups_Followup Gabapentin 5.24 (3.05-9.34)) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick excluded Adjustment: No Partial overlapping 0.64 [0.04;10.43] C
excluded (control group) 		0/43   194/10,769 194 43
ref
S17250
R72241		 Madley-Dowd_UK (Gabapentin) (Controls unexposed, sick) (Epilepsy), 2024 Intellectual disability - ICD10 codes - Median 4.93 (3.11-7.46) years old during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, sick Adjustment: No 8.60 [0.49;150.32] C 0/18   13/4,075 13 18
ref
Total 2 studies 2.30 [0.18;29.32] 207 61
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Madley-Dowd_SE (Gabapentin) (Controls unexposed, sick), 2024Madley-Dowd_SE, 2024 1 0.64[0.04; 10.43]1944351%ROB confusion: criticalROB selection: lowROB classification: lowROB missing: lowROB mesure: criticalROB reporting: moderate Madley-Dowd_UK (Gabapentin) (Controls unexposed, sick) (Epilepsy), 2024Madley-Dowd_UK, 2024 2 8.60[0.49; 150.32]131849%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 38% 2.30[0.18; 29.32]207610.220.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Gabapentin) (Controls unexposed, sick; 2: Gabapentin) (Controls unexposed, sick) (Epilepsy;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.30[0.18; 29.32]2076138%NAMadley-Dowd_SE (Gabapentin) (Controls unexposed, sick), 2024 Madley-Dowd_UK (Gabapentin) (Controls unexposed, sick) (Epilepsy), 2024 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.30[0.18; 29.32]2076138%NAMadley-Dowd_SE (Gabapentin) (Controls unexposed, sick), 2024 Madley-Dowd_UK (Gabapentin) (Controls unexposed, sick) (Epilepsy), 2024 2 Tags Adjustment   - No  - No 2.30[0.18; 29.32]2076138%NAMadley-Dowd_SE (Gabapentin) (Controls unexposed, sick), 2024 Madley-Dowd_UK (Gabapentin) (Controls unexposed, sick) (Epilepsy), 2024 2 All studiesAll studies 2.30[0.18; 29.32]2076138%NAMadley-Dowd_SE (Gabapentin) (Controls unexposed, sick), 2024 Madley-Dowd_UK (Gabapentin) (Controls unexposed, sick) (Epilepsy), 2024 20.220.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 17428, 17429

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.48[0.28; 7.97]4011047%NAMadley-Dowd_SE (Gabapentin) (Controls unexposed, sick), 2024 Madley-Dowd_SE (Gabapentin) (Controls unexposed, sick), 2024 Madley-Dowd_UK (Gabapentin) (Controls unexposed, sick) (Epilepsy), 2024 3 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.80[0.05; 13.28]3443 -NAMadley-Dowd_SE (Gabapentin) (Controls exposed to LTG), 2024 10.510.01.0