Gabapentin (Epilepsy) updated on 04-22-2025

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S16083
R66741		 Christensen (Gabapentin) (Epilepsy) (Controls exposed to LTG), 2024 Low birth weight (<2500 g) during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 1.36 [0.66;2.80] C
excluded (control group) 		8/138   230/5,299 238 138
ref
S16035
R66559		 Christensen (Gabapentin) (Epilepsy) (Controls unexposed, general population), 2024 Low birth weight (<2500 g) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 1.04 [0.50;2.14] 8/138   1,006/22,227 1,014 138
ref
Total 1 studies 1.04 [0.50;2.15] 1,014 138
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Christensen (Gabapentin) (Epilepsy) (Controls unexposed, general population), 2024Christensen, 2024 1 1.04[0.50; 2.14]1,0141380%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Gabapentin) (Epilepsy) (Controls unexposed, general population;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.04[0.50; 2.15]1,014138 -NAChristensen (Gabapentin) (Epilepsy) (Controls unexposed, general population), 2024 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.04[0.50; 2.15]1,014138 -NAChristensen (Gabapentin) (Epilepsy) (Controls unexposed, general population), 2024 1 Tags Adjustment   - Yes  - Yes 1.04[0.50; 2.15]1,014138 -NAChristensen (Gabapentin) (Epilepsy) (Controls unexposed, general population), 2024 1 All studiesAll studies 1.04[0.50; 2.15]1,014138 -NAChristensen (Gabapentin) (Epilepsy) (Controls unexposed, general population), 2024 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 16083

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.04[0.50; 2.15]1,014138 -NAChristensen (Gabapentin) (Epilepsy) (Controls unexposed, general population), 2024 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.36[0.66; 2.80]238138 -NAChristensen (Gabapentin) (Epilepsy) (Controls exposed to LTG), 2024 10.510.01.0