Gabapentin (Epilepsy) updated on 04-22-2025

Small for gestational age (weight)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S16083
R66742		 Christensen (Gabapentin) (Epilepsy) (Controls exposed to LTG), 2024 Small for gestational age (a z-score for birth weight ≤10th percentile for gestational week, sex, and country (including newborns with congenital malformations)) during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 1.06 [0.62;1.83] C
excluded (control group) 		15/138   546/5,299 561 138
ref
S16035
R66560		 Christensen (Gabapentin) (Epilepsy) (Controls unexposed, general population), 2024 Small for gestational age (a z-score for birth weight ≤10th percentile for gestational week, sex, and country (including newborns with congenital malformations)) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 0.91 [0.52;1.57] 15/138   2,416/22,227 2,431 138
ref
Total 1 studies 0.91 [0.52;1.58] 2,431 138
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Christensen (Gabapentin) (Epilepsy) (Controls unexposed, general population), 2024Christensen, 2024 1 0.91[0.52; 1.57]2,4311380%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Gabapentin) (Epilepsy) (Controls unexposed, general population;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.91[0.52; 1.58]2,431138 -NAChristensen (Gabapentin) (Epilepsy) (Controls unexposed, general population), 2024 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.91[0.52; 1.58]2,431138 -NAChristensen (Gabapentin) (Epilepsy) (Controls unexposed, general population), 2024 1 Tags Adjustment   - Yes  - Yes 0.91[0.52; 1.58]2,431138 -NAChristensen (Gabapentin) (Epilepsy) (Controls unexposed, general population), 2024 1 All studiesAll studies 0.91[0.52; 1.58]2,431138 -NAChristensen (Gabapentin) (Epilepsy) (Controls unexposed, general population), 2024 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 16083

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.91[0.52; 1.58]2,431138 -NAChristensen (Gabapentin) (Epilepsy) (Controls unexposed, general population), 2024 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.06[0.62; 1.83]561138 -NAChristensen (Gabapentin) (Epilepsy) (Controls exposed to LTG), 2024 10.510.01.0