Levetiracetam (Epilepsy) updated on 04-22-2025

Low Apgar score (< 7) (at 5 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5932
R15139		 Artama (Levetiracetam) (Controls exposed to Lamotrigine, sick), 2013 5-min Apgar <7 3rd trimester population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 1.60 [0.08;32.84] C
excluded (control group) 		0/12   3/132 3 12
ref
S5913
R14930		 Artama (Levetiracetam) (Controls unexposed, disease free), 2013 5-min Apgar <7 3rd trimester population based cohort retrospective unexposed, disease free excluded Adjustment: No 3.84 [0.23;65.16] C
excluded (control group) 		0/12   3,014/269,151 3,014 12
ref
S5921
R15026		 Artama (Levetiracetam) (Controls unexposed, sick), 2013 5-min Apgar <7 3rd trimester population based cohort retrospective unexposed, sick Adjustment: No 8.06 [0.39;165.09] C 0/12   3/652 3 12
ref
Total 1 studies 8.06 [0.39;165.09] 3 12
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Artama (Levetiracetam) (Controls unexposed, sick), 2013Artama, 2013 1 8.06[0.39; 165.09]3120%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Levetiracetam) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 8.06[0.39; 165.09]312 -NAArtama (Levetiracetam) (Controls unexposed, sick), 2013 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 8.06[0.39; 165.09]312 -NAArtama (Levetiracetam) (Controls unexposed, sick), 2013 1 Tags Adjustment   - No  - No 8.06[0.39; 165.09]312 -NAArtama (Levetiracetam) (Controls unexposed, sick), 2013 1 All studiesAll studies 8.06[0.39; 165.09]312 -NAArtama (Levetiracetam) (Controls unexposed, sick), 2013 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 5932, 5913

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.84[0.23; 65.16]3,01412 -NAArtama (Levetiracetam) (Controls unexposed, disease free), 2013 1 unexposed, sick controlsunexposed, sick controls 8.06[0.39; 165.09]312 -NAArtama (Levetiracetam) (Controls unexposed, sick), 2013 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.60[0.08; 32.84]312 -NAArtama (Levetiracetam) (Controls exposed to Lamotrigine, sick), 2013 10.510.01.0