Levetiracetam (Epilepsy)

Maternal liver disorder / failure during pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12502
R47874		 Mari (Levetiracetam), 2022 Iatrogenic hepatitis throughout pregnancy retrospective cohort exposed to other treatment, sick Adjustment: No 0.64 [0.01;34.59] C 0/17   0/11 0 17
ref
Total 1 studies 0.64 [0.01;34.59] 0 17
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Mari (Levetiracetam), 2022Mari, 2022 1 0.64[0.01; 34.59]0170%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: unclear0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Levetiracetam;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.64[0.01; 34.59]-17 -NAMari (Levetiracetam), 2022 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 0.64[0.01; 34.59]-17 -NAMari (Levetiracetam), 2022 1 Tags Adjustment   - No  - No 0.64[0.01; 34.59]-17 -NAMari (Levetiracetam), 2022 1 All studiesAll studies 0.64[0.01; 34.59]-17 -NAMari (Levetiracetam), 2022 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.64[0.01; 34.59]-17 -NAMari (Levetiracetam), 2022 10.510.01.0