Levetiracetam (Epilepsy) updated on 04-22-2025

Cognitive developmental disorders/delay (> 6 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S16766
R70403		 Stjerna (Levetiracetam) (Epilepsy), 2024 Full scale intelligence quotient (FSIQ continuous) - The Wechsler Intelligence Scale for Children (WISC-III) - At 6-7 years old throughout pregnancy retrospective cohort exposed to other treatment, sick Adjustment: Yes extrapolated (cont. endpoint) 1.23 [0.46;3.29] -/16   -/74 - 16
ref
Total 1 studies 1.23 [0.46;3.29] 0 16
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Stjerna (Levetiracetam) (Epilepsy), 2024Stjerna, 2024 1 1.23[0.46; 3.29]-160%ROB confusion: seriousROB selection: unclearROB classification: moderateROB missing: lowROB mesure: lowROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Levetiracetam) (Epilepsy;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.23[0.46; 3.29]-16 -NAStjerna (Levetiracetam) (Epilepsy), 2024 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 1.23[0.46; 3.29]-16 -NAStjerna (Levetiracetam) (Epilepsy), 2024 1 Tags Adjustment   - Yes  - Yes 1.23[0.46; 3.29]-16 -NAStjerna (Levetiracetam) (Epilepsy), 2024 1 extrapolated (cont. endpoint)extrapolated (cont. endpoint) 1.23[0.46; 3.29]-16 -NAStjerna (Levetiracetam) (Epilepsy), 2024 1 All studiesAll studies 1.23[0.46; 3.29]-16 -NAStjerna (Levetiracetam) (Epilepsy), 2024 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.23[0.46; 3.29]-16 -NAStjerna (Levetiracetam) (Epilepsy), 2024 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Veroniki b (NMA) (Epilepsy) (Cognitive develo ...Veroniki b (NMA) (Epilepsy) (Cognitive developmental delay) 3.46[0.65; 17.14]NA-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT-9 metaPregmetaPreg 1.23[0.46; 3.29]NaN%16----Stjerna (Levetiracetam) (Epilepsy), 2024 10.510.01.0