Topiramate (Epilepsy) updated on 04-22-2025

Maternal consequences (as a whole)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S16694
R70251		 Razaz (Topiramate), 2024 Severe maternal morbidity (severe preeclampsia, severe hemorrhage, surgical complications, sepsis, obstetric shock, cardiac complications, kidney failure, cerebrovascular morbidity, complications of anesthesia and obstetric interventions and/or severe mental health conditions) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 1.21 [0.64;2.31] 10/249   656/19,043 666 249
ref
Total 1 studies 1.21 [0.64;2.30] 666 249
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Razaz (Topiramate), 2024Razaz, 2024 1 1.21[0.64; 2.31]6662490%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Topiramate;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.21[0.64; 2.30]666249 -NARazaz (Topiramate), 2024 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.21[0.64; 2.30]666249 -NARazaz (Topiramate), 2024 1 Tags Adjustment   - Yes  - Yes 1.21[0.64; 2.30]666249 -NARazaz (Topiramate), 2024 1 All studiesAll studies 1.21[0.64; 2.30]666249 -NARazaz (Topiramate), 2024 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.21[0.64; 2.30]666249 -NARazaz (Topiramate), 2024 10.510.01.0