Topiramate (Epilepsy) updated on 04-22-2025

Spina bifida

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6315
R26053		 Veiby (Topiramate) (Controls exposed to Lamotrigine, sick), 2014 Spina bifida throughout pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 13.94 [0.27;711.36] C
excluded (control group) 		0/43   0/593 0 43
ref
S6312
R26065		 Veiby (Topiramate) (Controls unexposed, sick), 2014 Spina bifida throughout pregnancy population based cohort retrospective unexposed, sick Adjustment: No 12.67 [0.64;249.11] C 0/43   3/3,773 3 43
ref
Total 1 studies 12.67 [0.64;249.11] 3 43
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Veiby (Topiramate) (Controls unexposed, sick), 2014Veiby, 2014 1 12.67[0.64; 249.11]3430%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: moderateROB reporting: moderate0.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Topiramate) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 12.67[0.64; 249.11]343 -NAVeiby (Topiramate) (Controls unexposed, sick), 2014 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 12.67[0.64; 249.11]343 -NAVeiby (Topiramate) (Controls unexposed, sick), 2014 1 Tags Adjustment   - No  - No 12.67[0.64; 249.11]343 -NAVeiby (Topiramate) (Controls unexposed, sick), 2014 1 All studiesAll studies 12.67[0.64; 249.11]343 -NAVeiby (Topiramate) (Controls unexposed, sick), 2014 10.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 6315

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale12.67[0.64; 249.11]343 -NAVeiby (Topiramate) (Controls unexposed, sick), 2014 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale13.94[0.27; 711.36]-43 -NAVeiby (Topiramate) (Controls exposed to Lamotrigine, sick), 2014 10.510.01.0