Topiramate (Epilepsy) updated on 04-22-2025

ADHD (Attention deficit hyperactivity disorder): Risk

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7307
R28370		 Bromley (Topiramate), 2016 Maladaptive behavior: Attention (BASC) (5-9 years old) during pregnancy (anytime or not specified) retrospective cohort (registry) unexposed, sick Adjustment: No extrapolated (cont. endpoint) 1.00 [0.43;2.31] -/27   -/55 - 27
ref
Total 1 studies 1.00 [0.43;2.32] 0 27
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bromley (Topiramate), 2016Bromley, 2016 1 1.00[0.43; 2.31]-270%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.52.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Topiramate;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.00[0.43; 2.32]-27 -NABromley (Topiramate), 2016 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.00[0.43; 2.32]-27 -NABromley (Topiramate), 2016 1 Tags Adjustment   - No  - No 1.00[0.43; 2.32]-27 -NABromley (Topiramate), 2016 1 extrapolated (cont. endpoint)extrapolated (cont. endpoint) 1.00[0.43; 2.32]-27 -NABromley (Topiramate), 2016 1 All studiesAll studies 1.00[0.43; 2.32]-27 -NABromley (Topiramate), 2016 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.00[0.43; 2.32]-27 -NABromley (Topiramate), 2016 10.510.01.0