Topiramate (Epilepsy) updated on 04-22-2025

Nervous system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12871
R48603		 Thomas (Topiramate) (Controls exposed to Lamotrigine, sick), 2021 Neural malformations 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No 5.82 [0.11;313.84] C
excluded (control group) 		0/9   0/50 0 9
ref
S12872
R48613		 Thomas (Topiramate) (Controls unexposed, sick), 2021 Neural malformations 1st trimester prospective cohort unexposed, sick Adjustment: No 39.94 [0.75;2134.65] C 0/9   0/340 0 9
ref
Total 1 studies 39.94 [0.75;2134.65] 0 9
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Thomas (Topiramate) (Controls unexposed, sick), 2021Thomas, 2021 1 39.94[0.75; 2134.65]090%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.9100.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Topiramate) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 39.94[0.75; 2134.65]-9 -NAThomas (Topiramate) (Controls unexposed, sick), 2021 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 39.94[0.75; 2134.65]-9 -NAThomas (Topiramate) (Controls unexposed, sick), 2021 1 Tags Adjustment   - No  - No 39.94[0.75; 2134.65]-9 -NAThomas (Topiramate) (Controls unexposed, sick), 2021 1 All studiesAll studies 39.94[0.75; 2134.65]-9 -NAThomas (Topiramate) (Controls unexposed, sick), 2021 10.5100.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 12871

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale39.94[0.75; 2134.65]-9 -NAThomas (Topiramate) (Controls unexposed, sick), 2021 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 5.82[0.11; 313.84]-9 -NAThomas (Topiramate) (Controls exposed to Lamotrigine, sick), 2021 10.510.01.0