Clonazepam (Epilepsy) updated on 02-10-2025

Neuro-developmental disorders (as a whole)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12769
R48162		 Bjørk (Epilepsy) (Controls exposed to Lamotrigine, sick), 2022 Neurodevelopmental Disorder (ND): any diagnoses of autism spectrum disorder (F84.0, F84.1, F84.5) or intellectual disability (F70, F71, F72, F73) plus F84.3, F84.4, F84.8, F84.9, F79 - Median follow up clonazepam 9.5 (5.5-13.9) years old during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 3.05 [1.74;5.36] C
excluded (control group) 		15/318   81/5,073 96 318
ref
S12770
R48166		 Bjørk (Epilepsy) (Controls unexposed NOS), 2022 Neurodevelopmental Disorder (ND): any diagnoses of autism spectrum disorder (F84.0, F84.1, F84.5) or intellectual disability (F70, F71, F72, F73) plus F84.3, F84.4, F84.8, F84.9, F79 - Median follow up clonazepam 9.5 (5.5-13.9) years old during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: No 3.19 [1.90;5.35] C
excluded (control group) 		15/318   68,295/4,463,879 68,310 318
ref
S12771
R48169		 Bjørk (Epilepsy) (Controls unexposed, sick), 2022 Neurodevelopmental Disorder (ND): any diagnoses of autism spectrum disorder (F84.0, F84.1, F84.5) or intellectual disability (F70, F71, F72, F73) plus F84.3, F84.4, F84.8, F84.9, F79 - Median follow up clonazepam 9.5 (5.5-13.9) years old during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 1.00 [0.58;1.04] 15/318   443/21,634 458 318
ref
Total 1 studies 1.00 [0.75;1.34] 458 318
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bjørk (Epilepsy) (Controls unexposed, sick), 2022Bjørk, 2022 1 1.00[0.58; 1.04]4583180%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.52.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Epilepsy) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.00[0.75; 1.34]458318 -NABjørk (Epilepsy) (Controls unexposed, sick), 2022 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.00[0.75; 1.34]458318 -NABjørk (Epilepsy) (Controls unexposed, sick), 2022 1 Tags Adjustment   - Yes  - Yes 1.00[0.75; 1.34]458318 -NABjørk (Epilepsy) (Controls unexposed, sick), 2022 1 All studiesAll studies 1.00[0.75; 1.34]458318 -NABjørk (Epilepsy) (Controls unexposed, sick), 2022 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 12769, 12770

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.19[1.90; 5.35]68,310318 -NABjørk (Epilepsy) (Controls unexposed NOS), 2022 1 unexposed, sick controlsunexposed, sick controls 1.00[0.75; 1.34]458318 -NABjørk (Epilepsy) (Controls unexposed, sick), 2022 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 3.05[1.74; 5.36]96318 -NABjørk (Epilepsy) (Controls exposed to Lamotrigine, sick), 2022 10.510.01.0