Clonazepam (Epilepsy) updated on 02-10-2025

Neonatal disorders (as a whole)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6688
R18694		 D'Souza (Epilepsy) (Controls unexposed, disease free), 1991 Neonatal conditions throughout pregnancy prospective cohort unexposed, disease free excluded Adjustment: No Matched 8.54 [0.16;467.74] C
excluded (control group) 		0/1   6/62 6 1
ref
S6696
R18855		 D'Souza (Epilepsy) (Controls unexposed, sick), 1991 Neonatal conditions throughout pregnancy prospective cohort unexposed, sick Adjustment: No 2.20 [0.03;146.04] C 0/1   2/8 2 1
ref
Total 1 studies 2.20 [0.03;146.04] 2 1
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF D'Souza (Epilepsy) (Controls unexposed, sick), 1991D'Souza, 1991 1 2.20[0.03; 146.04]210%ROB confusion: criticalROB selection: unclearROB classification: lowROB missing: unclearROB mesure: lowROB reporting: moderate0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Epilepsy) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.20[0.03; 146.04]21 -NAD'Souza (Epilepsy) (Controls unexposed, sick), 1991 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.20[0.03; 146.04]21 -NAD'Souza (Epilepsy) (Controls unexposed, sick), 1991 1 Tags Adjustment   - No  - No 2.20[0.03; 146.04]21 -NAD'Souza (Epilepsy) (Controls unexposed, sick), 1991 1 All studiesAll studies 2.20[0.03; 146.04]21 -NAD'Souza (Epilepsy) (Controls unexposed, sick), 1991 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 6688

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 8.54[0.16; 467.74]61 -NAD'Souza (Epilepsy) (Controls unexposed, disease free), 1991 1 unexposed, sick controlsunexposed, sick controls 2.20[0.03; 146.04]21 -NAD'Souza (Epilepsy) (Controls unexposed, sick), 1991 10.510.01.0