Lamotrigine (Epilepsy)

Neonatal medical care

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15841
R65206		 Bromley (Lamotrigine) (Epilepsy), 2023 Neonatal special care admission during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 2.87 [1.09;7.52] C 20/106   6/80 26 106
ref
S12612
R47535		 Van Marter (Controls unexposed, disease free), 2021 Need for special care nursery or neonatal intensive care unit (NICU) admission at least 1st trimester prospective cohort unexposed, disease free excluded Adjustment: No 1.25 [0.56;2.74] C
excluded (control group) 		16/102   13/100 29 102
ref
S12614
R47547		 Van Marter (Controls unexposed, sick), 2021 Need for special care nursery or neonatal intensive care unit (NICU) admission at least 1st trimester excluded prospective cohort unexposed, sick Adjustment: No 1.12 [0.23;5.47] C
excluded (exposition period) 		16/102   2/14 18 102
ref
S8077
R24652		 Aydin, 2020 Neonatal intensive care unit (NICU) throughout pregnancy retrospective cohort unexposed, sick Adjustment: No 4.00 [0.45;35.79] C 2/7   2/22 4 7
ref
S5912
R14916		 Artama (Controls unexposed, disease free), 2013 Admission to neonatal care unit 3rd trimester population based cohort retrospective unexposed, disease free excluded Adjustment: Yes 1.97 [1.26;3.08]
excluded (control group) 		24/154   49,612/689,482 49,636 154
ref
S5920
R15012		 Artama (Controls unexposed, sick), 2013 Admission to neonatal care unit 3rd trimester population based cohort retrospective unexposed, sick Adjustment: Yes 1.38 [0.55;3.47] 24/154   152/1,708 176 154
ref
Total 3 studies 2.08 [1.10;3.93] 206 267
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bromley (Lamotrigine) (Epilepsy), 2023Bromley, 2023 1 2.87[1.09; 7.52]2610644%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: moderateROB reporting: low Aydin, 2020Aydin, 2020 4.00[0.45; 35.79]478%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Artama (Controls unexposed, sick), 2013Artama, 2013 2 1.38[0.55; 3.47]17615448%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 0% 2.08[1.10; 3.93]2062670.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Lamotrigine) (Epilepsy; 2: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.08[1.10; 3.93]2062670%NABromley (Lamotrigine) (Epilepsy), 2023 Aydin, 2020 Artama (Controls unexposed, sick), 2013 3 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.08[1.10; 3.93]2062670%NABromley (Lamotrigine) (Epilepsy), 2023 Aydin, 2020 Artama (Controls unexposed, sick), 2013 3 Tags Adjustment   - No  - No 3.03[1.25; 7.31]301130%NABromley (Lamotrigine) (Epilepsy), 2023 Aydin, 2020 2   - Yes  - Yes 1.38[0.55; 3.47]176154 -NAArtama (Controls unexposed, sick), 2013 1 All studiesAll studies 2.08[1.10; 3.93]2062670%NABromley (Lamotrigine) (Epilepsy), 2023 Aydin, 2020 Artama (Controls unexposed, sick), 2013 30.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 5912, 12612

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.97[1.26; 3.08]49,636154 -NAArtama (Controls unexposed, disease free), 2013 1 unexposed, sick controlsunexposed, sick controls 2.08[1.10; 3.93]2062670%NABromley (Lamotrigine) (Epilepsy), 2023 Aydin, 2020 Artama (Controls unexposed, sick), 2013 30.510.01.0