Lamotrigine (Epilepsy)

Gestational diabetes

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8077
R24654		 Aydin, 2020 Gestational diabetes mellitus throughout pregnancy retrospective cohort unexposed, sick Adjustment: No 1.05 [0.04;29.08] C 0/7   1/22 1 7
ref
S6295
R17032		 Rihtman, 2013 Mothers: gestational diabetes in pregnancy at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No 1.28 [0.02;65.87] C 0/40   0/51 0 40
ref
Total 2 studies 1.14 [0.09;14.45] 1 47
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Aydin, 2020Aydin, 2020 1.05[0.04; 29.08]1759%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Rihtman, 2013Rihtman, 2013 1.28[0.02; 65.87]04041%ROB confusion: unclearROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.14[0.09; 14.45]1470.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.14[0.09; 14.45]1470%NAAydin, 2020 Rihtman, 2013 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.28[0.02; 65.87]-40 -NARihtman, 2013 1 unexposed, sickunexposed, sick 1.05[0.04; 29.08]17 -NAAydin, 2020 1 Tags Adjustment   - No  - No 1.14[0.09; 14.45]1470%NAAydin, 2020 Rihtman, 2013 2 All studiesAll studies 1.14[0.09; 14.45]1470%NAAydin, 2020 Rihtman, 2013 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.28[0.02; 65.87]-40 -NARihtman, 2013 1 unexposed, sick controlsunexposed, sick controls 1.05[0.04; 29.08]17 -NAAydin, 2020 10.510.01.0