Lamotrigine (Epilepsy)

Postpartum hemorrhage

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6260
R16725		 Borthen (Controls unexposed, disease free), 2010 Haemorrhage ≥ 500 ml during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free excluded Adjustment: Yes 1.60 [1.20;2.20]
excluded (control group) 		48/233   49,252/362,302 49,300 233
ref
S6265
R16765		 Borthen (Controls unexposed, sick), 2010 Haemorrhage ≥ 500 ml during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: No 1.49 [1.06;2.10] C 48/233   276/1,863 324 233
ref
Total 1 studies 1.49 [1.06;2.10] 324 233
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Borthen (Controls unexposed, sick), 2010Borthen, 2010 1 1.49[1.06; 2.10]3242330%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.49[1.06; 2.10]324233 -NABorthen (Controls unexposed, sick), 2010 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.49[1.06; 2.10]324233 -NABorthen (Controls unexposed, sick), 2010 1 Tags Adjustment   - No  - No 1.49[1.06; 2.10]324233 -NABorthen (Controls unexposed, sick), 2010 1 All studiesAll studies 1.49[1.06; 2.10]324233 -NABorthen (Controls unexposed, sick), 2010 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 6260

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.60[1.18; 2.17]49,300233 -NABorthen (Controls unexposed, disease free), 2010 1 unexposed, sick controlsunexposed, sick controls 1.49[1.06; 2.10]324233 -NABorthen (Controls unexposed, sick), 2010 10.510.01.0