Lamotrigine (Epilepsy)

Assisted deliveries (forceps, vacuum, ...)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6295
R17035		 Rihtman, 2013 Vacuum and/or forceps assisted childbirth at least 1st trimester excluded prospective cohort unexposed (general population or NOS) Adjustment: No 1.68 [0.42;6.71] C
excluded (exposition period) 		5/40   4/51 9 40
ref
S6260
R16723		 Borthen (Controls unexposed, disease free), 2010 Delivery Cephalic vaginal with forceps or vacuum during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free excluded Adjustment: Yes 1.40 [0.90;2.00]
excluded (control group) 		30/233   28,546/362,302 28,576 233
ref
S6265
R16763		 Borthen (Controls unexposed, sick), 2010 Delivery Cephalic vaginal with forceps or vacuum during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: No 1.63 [1.07;2.47] C 30/233   155/1,863 185 233
ref
Total 1 studies 1.63 [1.07;2.47] 185 233
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Borthen (Controls unexposed, sick), 2010Borthen, 2010 1 1.63[1.07; 2.47]1852330%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.63[1.07; 2.47]185233 -NABorthen (Controls unexposed, sick), 2010 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.63[1.07; 2.47]185233 -NABorthen (Controls unexposed, sick), 2010 1 Tags Adjustment   - No  - No 1.63[1.07; 2.47]185233 -NABorthen (Controls unexposed, sick), 2010 1 All studiesAll studies 1.63[1.07; 2.47]185233 -NABorthen (Controls unexposed, sick), 2010 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 6260

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.40[0.94; 2.09]28,576233 -NABorthen (Controls unexposed, disease free), 2010 1 unexposed, sick controlsunexposed, sick controls 1.63[1.07; 2.47]185233 -NABorthen (Controls unexposed, sick), 2010 10.510.01.0