Lamotrigine (Epilepsy) updated on 04-22-2025

Microcephaly / Small head circumference for gestational age

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S16017
R66492		 Christensen (Lamotrigine) (Epilepsy), 2024 Microcephaly (z-score for head circumference ≤3rd percentile for gestational week, sex, and country (including newborns with congenital malformations)) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 0.88 [0.73;1.06] 151/5,299   699/22,227 850 5,299
ref
Total 1 studies 0.88 [0.73;1.06] 850 5,299
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Christensen (Lamotrigine) (Epilepsy), 2024Christensen, 2024 1 0.88[0.73; 1.06]8505,2990%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Lamotrigine) (Epilepsy;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.88[0.73; 1.06]8505,299 -NAChristensen (Lamotrigine) (Epilepsy), 2024 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.88[0.73; 1.06]8505,299 -NAChristensen (Lamotrigine) (Epilepsy), 2024 1 Tags Adjustment   - Yes  - Yes 0.88[0.73; 1.06]8505,299 -NAChristensen (Lamotrigine) (Epilepsy), 2024 1 All studiesAll studies 0.88[0.73; 1.06]8505,299 -NAChristensen (Lamotrigine) (Epilepsy), 2024 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.88[0.73; 1.06]8505,299 -NAChristensen (Lamotrigine) (Epilepsy), 2024 10.510.01.0