Lamotrigine (Epilepsy) updated on 04-22-2025

Low Apgar score (< 7) (at 1 min)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S5912
R14917		 Artama (Controls unexposed, disease free), 2013 1-min Apgar <7 3rd trimester population based cohort retrospective unexposed, disease free excluded Adjustment: Yes 1.15 [0.59;2.27]
excluded (control group) 		9/154   27,939/689,482 27,948 154
ref
S5920
R15013		 Artama (Controls unexposed, sick), 2013 1-min Apgar <7 3rd trimester population based cohort retrospective unexposed, sick Adjustment: Yes 1.69 [0.35;8.12] 9/154   69/1,708 78 154
ref
Total 1 studies 1.69 [0.35;8.14] 78 154
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Artama (Controls unexposed, sick), 2013Artama, 2013 1 1.69[0.35; 8.12]781540%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.69[0.35; 8.14]78154 -NAArtama (Controls unexposed, sick), 2013 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.69[0.35; 8.14]78154 -NAArtama (Controls unexposed, sick), 2013 1 Tags Adjustment   - Yes  - Yes 1.69[0.35; 8.14]78154 -NAArtama (Controls unexposed, sick), 2013 1 All studiesAll studies 1.69[0.35; 8.14]78154 -NAArtama (Controls unexposed, sick), 2013 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 5912

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.15[0.59; 2.26]27,948154 -NAArtama (Controls unexposed, disease free), 2013 1 unexposed, sick controlsunexposed, sick controls 1.69[0.35; 8.14]78154 -NAArtama (Controls unexposed, sick), 2013 10.510.01.0