Lamotrigine (Epilepsy)

Severe cognitive developmental delay (Mental retardation) (> 6 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15870
R65386		 Dreier, 2023 Intellectual disability - Corresponding ICD-10 F-chapter - Up to 22 years of age during pregnancy (anytime or not specified) population based cohort propective unexposed, sick Adjustment: Yes 0.85 [0.58;1.24] 34/5,288   184/22,203 218 5,288
ref
Total 1 studies 0.85 [0.58;1.24] 218 5,288
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Dreier, 2023Dreier, 2023 0.85[0.58; 1.24]2185,2880%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.85[0.58; 1.24]2185,288 -NADreier, 2023 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.85[0.58; 1.24]2185,288 -NADreier, 2023 1 Tags Adjustment   - Yes  - Yes 0.85[0.58; 1.24]2185,288 -NADreier, 2023 1 All studiesAll studies 0.85[0.58; 1.24]2185,288 -NADreier, 2023 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.85[0.58; 1.24]2185,288 -NADreier, 2023 10.510.01.0