Lamotrigine (Epilepsy) updated on 04-22-2025

Minor congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15841
R65209		 Bromley (Lamotrigine) (Epilepsy), 2023 Minor congenital anomaly during pregnancy (anytime or not specified) excluded prospective cohort unexposed, sick Adjustment: No 6.45 [0.79;52.66] C
excluded (exposition period) 		8/106   1/80 9 106
ref
S16699
R70267		 Alsaadi (Controls unexposed sick), 2020 Minor congenital malformations 1st trimester retrospective cohort unexposed, sick Adjustment: No 10.14 [0.38;267.91] C 1/12   0/36 1 12
ref
Total 1 studies 10.14 [0.38;267.91] 1 12
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Alsaadi (Controls unexposed sick), 2020Alsaadi, 2020 1 10.14[0.38; 267.91]1120%ROB confusion: criticalROB selection: unclearROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate0.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 10.14[0.38; 267.91]112 -NAAlsaadi (Controls unexposed sick), 2020 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 10.14[0.38; 267.91]112 -NAAlsaadi (Controls unexposed sick), 2020 1 Tags Adjustment   - No  - No 10.14[0.38; 267.91]112 -NAAlsaadi (Controls unexposed sick), 2020 1 All studiesAll studies 10.14[0.38; 267.91]112 -NAAlsaadi (Controls unexposed sick), 2020 10.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale10.14[0.38; 267.91]112 -NAAlsaadi (Controls unexposed sick), 2020 10.510.01.0